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0 · Scientists uncover new and “unexpected” information about
1 · Celine Valant's research works
2 · Celine Valant — Monash University
3 · Celine Valant
4 · Analytical & Structural Neuropharmacology
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Post-doctoral Fellow. Faculty of Pharmacy and Pharmaceutical Sciences. Drug .Celine Valant's 85 research works with 4,134 citations and 9,946 reads, including: Xanomeline .Celine Valant. Assessing the bias profile of xanomeline at M1-M5 mAChRs. 2022-09 to 2023 . The new study, published in the prestigious journal, Nature Communications, .
Analytical & Structural Neuropharmacology. Dr Celine Valant. Dr David Thal. Professor Arthur . Celine Valant 1 , Lauren T May, Luigi Aurelio, Chung Hui Chuo, Paul J White, Jo-Anne Baltos, Patrick M Sexton, Peter J Scammells, Arthur Christopoulos Affiliation 1 Drug Discovery Biology and Department of Pharmacology and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
5 Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia; [email protected] [email protected] [email protected]. PMID: 27601651Conway, Richard ; Valant, Celine; Christopoulos, Arthur et al. / Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C .
Scientists uncover new and “unexpected” information about
Dr Celine Valant Dr David Thal Professor Arthur Christopoulos, FAA FAHMS. Understanding the molecular basis and physiological consequences of allosteric modulation and biased agonism at G protein-coupled receptors.Briana J. Davie, Celine Valant, Jonathan M. White, Patrick M. Sexton, Ben Capuano, Arthur Christopoulos, and Peter J. Scammells. Synthesis and Pharmacological Evaluation of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) Designed to Bind Irreversibly to an Allosteric Site of the M1 Muscarinic Acetylcholine Receptor.Celine Valant. Supervisor. Dr Celine Valant. We acknowledge and pay respects to the Elders and Traditional Owners of the land on which our Australian campuses stand. Information for Indigenous Australians. Community. Faculties Locations Diversity and .
Celine Valant. View author publications. You can also search for this author in PubMed Google Scholar. Ron O. Dror .
Celine Valant. View author publications. You can also search for this author in PubMed Google Scholar . Throughout the 2000s and into the 2010s, the Analytical and Structural Neuropharmacology Laboratory within the Monash Institute of Pharmaceutical Sciences (MIPS), Faculty of Pharmacy and Pharmaceutical Sciences, co-led by Professor Christopoulos and Associate Professors Celine Valant and David Thal, worked in collaboration with Dr Christian .Valant, Celine; May, Lauren Therese; Aurelio, Luigi et al. / Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. In: Proceedings of the National Academy of Sciences of the United States .A drug's selectivity for target receptors is essential to its therapeutic utility, but achieving selectivity between similar receptors is challenging. The serendipitous discovery of ligands that stimulate target receptors more strongly than closely related receptors, despite binding with similar aff .
Celine Valant, Email: [email protected]. Ron O. Dror, Email: [email protected]. Extended data. is available for this paper at 10.1038/s41589-022-01247-5. Supplementary information. The online version contains supplementary material available at 10.1038/s41589-022-01247-5.Celine Valant. 2013, Nature. See full PDF download Download PDF. Related papers. Allosteric modulation of muscarinic acetylcholine receptors. J. Proska. Trends in pharmacological sciences, 1995. Five subtypes of muscarinic acetylcholine receptors have been identified in mammalian tissues, but the selectivity of ligands that are active at these .Celine Valant. Biochemical pharmacology, 2018. Subtype-selective allosteric modulation of the M muscarinic acetylcholine (ACh) receptor (M mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quinolone carboxylic acid, BQCA, a selective M mAChR positive allosteric .
Celine Valant. Monash University - Drug Discovery Biology ( email) Parkville, VIC 3052 Australia. Yinglong Miao. University of Kansas - Center for Computational Biology and Department of Molecular Biosciences ( email) KS 66045 United States. Arthur Christopoulos.AU - Valant, Celine. AU - Dror, Ron O. N1 - Funding Information: We thank D. Aydin, S. Hollingsworth and M. Popiolek for discussions and advice. Funding was provided by a National Science Foundation Graduate Research Fellowship (A.S.P.), the Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training Program under National Institutes of . Celine Valant. View author publications. You can also search for this author in PubMed Google Scholar. Ron O. Dror .
Celine Valant. 2021, Nature. See full PDF download Download PDF. Related papers. . J Med Chem, 2009. 52(14): p. 4543–7. [PubMed: 19514747] 24. Valant C, et al. , Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Proc Natl Acad Sci U S A, 2014. 111(12): p. 4614–9. .
Celine Valant. Monash University - Drug Discovery Biology. Christopher J. Langmead. Monash University - Monash Institute of Pharmaceutical Sciences. Abstract. The histamine H3 receptor (H3R) is a neurotransmitter receptor that is primarily found in the brain, where it controls the release and synthesis of histamine, as well as the release of .
Magdalena Korczynska, a, 1 Mary J. Clark, b, 1 Celine Valant, c, 1 Jun Xu, d Ee Von Moo, c Sabine Albold, c Dahlia R. Weiss, a Hayarpi Torosyan, a Weijiao Huang, e Andrew C. Kruse, f Brent R. Lyda, b Lauren T. May, c Jo-Anne Baltos, c Patrick M. Sexton, c Brian K. Kobilka, d, e Arthur Christopoulos, c, 2 Brian K. Shoichet, a, 2 and Roger K .Huynh, Tracey ; Valant, Celine; Crosby, Ian Travers et al. / Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.In . Jack K McDonald 1 , Emma T van der Westhuizen 1 , Vi Pham 1 , Geoff Thompson 1 , Christian C Felder 2 , Steven M Paul 2 , David M Thal 1 3 , Arthur Christopoulos 1 3 , Celine Valant 1 3 Affiliations
Positive allosteric modulators (PAMs) targeting the M 4 muscarinic acetylcholine receptor (mAChR) offer greater sub-type selectivity and unique potential as central nervous system agents through their novel mode of action to traditional orthosteric ligands. In an attempt to elucidate the molecular determinants of allostery mediated by the exemplar thienopyridine M 4 mAChR .Dr Celine Valant, Drug Discovery Biology, MIPS; Modulation of glucagon-like peptide 1 receptor signaling, regulation and physiology to treat metabolic disease. Dr Kyle Sloop, Eli Lilly, USA; Dr Francis Willard, Eli Lilly, USA; Professor Arthur Christopoulos, Drug Discovery Biology, MIPS; Professor Larry Miller, Mayo Clinic, USA
Celine Valant's research works
Celine Valant. 2019. The human M5 muscarinic acetylcholine receptor (mAChR) has recently emerged as an exciting therapeutic target for treating a range of disorders, including drug addiction. However, a lack of structural information for this receptor subtype has limited further drug development and validation. Here we report a high-resolution .
The human M 5 muscarinic acetylcholine receptor (mAChR) has recently emerged as an exciting therapeutic target for treating a range of disorders, including drug addiction. However, a lack of structural information for this receptor subtype has limited further drug development and validation. Here we report a high-resolution crystal structure of the human M . Celine Valant, a, 1 Lauren T. May, a, 1 Luigi Aurelio, b Chung Hui Chuo, a Paul J. White, a Jo-Anne Baltos, a Patrick M. Sexton, a Peter J. Scammells, b, 2 and Arthur Christopoulos a, 2 Celine Valant a Drug Discovery Biology and Department of Pharmacology and
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Celine Valant — Monash University
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celine valant|Celine Valant's research works
